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. 2017 Jun 14;7:3470. doi: 10.1038/s41598-017-03687-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MCODE network clustering analysis. Illustration of the identified cluster by the network clustering algorithm MCODE showing the interaction between ID4, ID1, BMP2, SMAD9, TGF-beta signaling, BMP signalling and ALK1 signaling. The circles are genes and the rhomboids are protein domains. Green lines represent genetic interactions. Green circles indicate downregulated genes in S vs A and the purple circle indicates upregulated gene in S vs A. Blue lines represents pathways. Grey lines indicate gene-pathway associations.