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. 2017 Jun 14;7:3524. doi: 10.1038/s41598-017-01675-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Class I and II fate transformations resemble normal hypodermal differentiation. (a,b) Worms with the dual-colour fate reporter ouIs10 and the integrated apical junction marker ouIs21 (strain AW1106) were subjected to nmy-2 knockdown and representative snapshots were taken after the L3 division. (a) Class I phenotype. Arrow points to the broken apical junction in a seam daughter that should normally be protected from receiving differentiation signals. Arrowhead points to a Class II event next to a Class I event in the same worm. (b) Class II phenotype. Arrow points to the broken apical junction in a seam daughter that should normally be protected from receiving differentiation signals. Arrowhead points to a cell at the transitional stage where the hypodermal marker is expressed more strongly in the anterior nucleus than the posterior one. (c) Wild-type seam syncytium produced smooth, continuous alae (between dotted lines) (strain AW335). (d) The nmy-2 knockdown animal had missing seam nuclei (white arrows) that correlated with absent (brackets) or broken (black arrows) alae ridges (strain AW785). Young adults were imaged in (c) and (d).