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. 2017 Jun 14;7:3504. doi: 10.1038/s41598-017-03276-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In-vivo SPECT/CT imaging and pathological results. (a) In vivo micro-SPECT/CT images of ^99mTc-MAG₃-bevacizumab (sagittal, coronal, and transverse views, left to right) in an ApoE^−/− mouse. (b) The gross morphology of aortic plaque. (c) IHC results of slices from intense radioactivity accumulated plaque area in aortic arch, CD31 immunohistochemical image (×100), higher magnification (×400), VEGF immunohistochemical image (×100) and higher magnification (×400) displayed from left to right in turn. (d) IHC results of slices from intense radioactivity accumulated plaque area in thoracic aorta, CD31 immunohistochemical image (×100), higher magnification (×400), VEGF immunohistochemical image (×100) and higher magnification (×400) displayed from left to right in turn.