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. 2017 Jun 14;7:3458. doi: 10.1038/s41598-017-02774-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of PRM on HIF-1α, TLR-4, PDGF-BB and FGF-2 expression in CoCl₂ stimulated HLF-1. (A) Representative light microscopic appearance of normal HLF-1 cells (A1), CoCl₂-treated cells (A2), and cells treated with CoCl₂ +0.3 mg/mL PRM (A3). (B and C), HLF-1 cells were incubated with CoCl₂ (100 μM) for 48 h. HMGB1, HIF-1α, TLR-4, PDGF-BB and FGF-2 expression was analyzed by western blot. The results are reported as percent increase over normal. Data are reported as the mean ± S.D., n = 5. ^#P < 0.01 vs. the normal group; ^*P < 0.05, ^**P < 0.01 vs. the CoCl₂ stimulated group. Significance was determined by one-way ANOVA followed by Dunnett’s test. The full-length blots of Fig. 5A are presented in Supplementary information 2.3.