Table 3.
The main pharmacokinetic parameters of calycosin, calycosin-7-O-glucoside, formononetin, ononin and mangiferin after the oral administration of PRM (mean ± SD; n = 6).
| Parameter | Group | AUC(0-t) (ng × h/mL) | AUC(0-∞) (ng × h/mL) | C max (ng/mL) | T 1/2 (h) | T max (h) |
|---|---|---|---|---|---|---|
| calycosin | Normal | 66.3 ± 31.5 | 68.1 ± 32.3 | 11.2 ± 5.7 | 4.1 ± 1.7 | 2.8 ± 1.6 |
| PF | 142.9 ± 56.7* | 153.5 ± 60.2* | 16.3 ± 4.2 | 6.1 ± 0.9* | 2.5 ± 0.8 | |
| calycosin-7-O-glucoside | Normal | 10.2 ± 2.0 | 28.2 ± 5.3 | 1.5 ± 1.0 | 34.7 ± 10.9 | 0.6 ± 0.4 |
| PF | 10.3 ± 3.7 | 26.0 ± 11.7 | 1.5 ± 0.8 | 27.5 ± 15.3 | 1.3 ± 1.1 | |
| formononetin | Normal | 7.2 ± 3.9 | 7.7 ± 4.1 | 2.5 ± 1.8 | 2.3 ± 1.3 | 1.3 ± 1.0 |
| PF | 6.6 ± 3.1 | 8.3 ± 4.1 | 1.6 ± 0.7 | 6.1 ± 2.1* | 1.9 ± 1.0 | |
| ononin | Normal | 24.8 ± 8.1 | 28.2 ± 9.9 | 4.9 ± 1.2 | 5.6 ± 3.2 | 1.4 ± 0.9 |
| PF | 17.1 ± 4.5 | 18.4 ± 4.8 | 7.2 ± 2.1 | 2.4 ± 0.5 | 0.6 ± 0.4 | |
| mangiferin | Normal | 75.0 ± 27.3 | 111.9 ± 47.4 | 16.3 ± 5.9 | 17.2 ± 11.3 | 3.0 ± 1.4 |
| PF | 20.1 ± 7.6* | 25.6 ± 7.8* | 4.4 ± 2.2* | 10.7 ± 5.2 | 4.8 ± 2.7 |
* P < 0.05 compared with the normal group.