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. 2017 Jun 14;7:3491. doi: 10.1038/s41598-017-03675-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Andrographolide (ANDRO) modulates CDAA-diet-induced inflammasome activation. Mice were fed with choline-deficient amino acid-defined (CDAA) or choline-supplemented L-amino acid defined (CSAA) diets during 22 weeks and treated with ANDRO or Vehicle (V) as described in material and methods. RNA was isolated from liver tissue and mRNA levels of (A) anti-Apoptosis-Associated Speck-Like Protein Containing CARD (ASC), (B) Nucleotide-binding oligomerization domain leucine-rich-repeat containing receptor 3 (NLRP3), (C) Caspase-1 (CASP1) and (D) interleukin-1β (IL-1β) were assessed by real time PCR. Statistical significance was evaluated using ANOVA with a post-hoc Bonferroni multiple-comparison test (*p ≤ 0.05 and ***p ≤ 0.001).