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. 2017 Jun 14;7:3494. doi: 10.1038/s41598-017-03796-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Parameters of systemic and hepatic inflammation in control- and PepA-injected mice. (A) Absolute levels of leukocyte, T cell, monocyte and B cell populations at week 2 and 3 of the experiment. (B) Liver sections were stained for infiltrating macrophages and neutrophils (Mac-1), T cells (CD3) and resident monocytes/macrophages (CD68). Positive cells were counted (infiltrated macrophages/neutrophils and T cells) or scored (CD68). (C,D) Representative pictures of the Mac-1 (C) and CD68 staining (D) (original magnification, 200x). (E) Gene expression analysis of Tnfα, Ccl2, Caspase1 and Cd68. Data are shown relative to control mice on chow diet. Error bars represent ± SEM; *indicates p ≤ 0.05 and ***p < 0.001 compared to mice on chow diet; ^#indicates p ≤ 0.05 and ^### p < 0.001 compared to control-injected mice on HFC diet by use of two-tailed unpaired t test; for FACS n = 4 animals per group and for immunohistochemistry and gene expression n = 8–11 animals per group.