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. 2017 Jun 14;7:3494. doi: 10.1038/s41598-017-03796-5

Figure 2.

Figure 2

Parameters of lysosomal function in control- and PepA-injected mice. (A,B) Plasma (A) and hepatic (B) activity of CTSD. (C) Hepatic gene expression analysis of Ctsd. Data are shown relative to control mice on chow diet by use of two-tailed unpaired t test. (D) Plasma levels of CTSD. (E–G) Correlation between plasma levels of CTSD and hepatic gene expression of Tnfα, Ccl2 and Caspase1 by Pearson correlation. Error bars represent ± SEM. **Indicates p < 0.01 and ***p < 0.001 compared to mice on chow diet; #indicates p ≤ 0.05, ## p < 0.01 and ### p < 0.001 compared to control-injected mice on HFC diet by use of two-tailed unpaired t test. n = 9–11 animals in each group. For correlation analysis, n = 4 animals on chow diet and n = 10 for mice on HFC diet.