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. 2017 Jun 14;7:3494. doi: 10.1038/s41598-017-03796-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic overview illustrating the proposed by which CTSD participates in the development of hepatic inflammation. Based on findings of the current study, increased levels of CTSD lead to a disturbance in lipid metabolism, which is known to result in increased plasma cholesterol (hypercholesterolemia) and triglyceride (hypertriglyceridemia) levels. Consequently, hypercholesterolemia and hypertriglyceridemia can lead to hepatic inflammation.