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. 2017 Jun 14;7:3539. doi: 10.1038/s41598-017-03813-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BzATP increases 8-oxo-dG in spinal cord dorsal horn neurons in vivo. Left panel: Confocal images of BzATP-induced oxidative DNA damage as marked by 8-oxo-dG (green) with and without PBN pre-treatment. Spinal cords were double stained with NeuN, a neuronal marker (red). Top right panel: Summary of 8-oxo-dG intensity in BzATP-induced oxidative DNA damage. Bottom right panel: Percent colocalization of 8-oxo-dG expressing neurons. Values represent mean ± SEM, n = 3–5. ***P < 0.001 when compared to control, ^##P < 0.01, ^### P < 0.001 when compared to BzATP by the one-way ANOVA. Scale bar 100 µm.