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. 2017 Jun 14;7:3542. doi: 10.1038/s41598-017-03760-3

Figure 5.

Figure 5

GGT expression in resected tissues. (a) Immunohistochemical staining of GGT in tissue samples showing the grades assigned according to the cell membrane staining pattern: Grades 1, 2, and 3 correspond to lower, equivalent, or higher, respectively, staining intensity in cancerous tissues compared with non-cancerous liver parenchyma. (b) Proportion of the indicated tumor samples with GGT staining Grades 1, 2, and 3. Staining intensity tended to be higher in 23 High-gGlu-HMRG HCCs (21 samples Grade 2 or 3) than in 17 Low-gGlu-HMRG HCCs (6 samples Grade 2 or 3, P < 0.001). All 7 ICCs and 34 CRLMs examined were classified as Grade 3. (c) In 9 patients (10 metastatic tumors) with synchronous CRLM, the “stain rate” (proportion of cancerous tissue stained vs. unstained) in the hepatic metastases were positively correlated with and tended to be higher than the stain rates of the corresponding primary colorectal cancers (Pearson’s correlation coefficient r = 0.873, y = 1.28× + 9.76, P = 0.001).