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. 2017 Jun 14;7:3459. doi: 10.1038/s41598-017-03811-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Elevated expression of integrin, MMP9, and phosphodiesterase (PDE) in TMD cells. (A,B) Elevated integrin β subunits (B3, B4, B5, and B8) in TMD cells. (C,D) Messenger RNA level and activity of MMP9. (E) Comparison of the mRNA levels of the selected PDEs (8B, 1C, 4B, and 5A) in TMD and BMD cells. (F) Reduction in the mRNA levels of the selected PDEs in TMD cells by GRM3 siRNA. NC = non-specific control siRNA.