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. 2017 Jun 14;7:66. doi: 10.1186/s13613-017-0286-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Experimental design. After catheter insertion and surgical CLP, rats were randomized into the 0.9% NaCl or PlasmaLyte^® groups. After randomization (T0, supervision baseline), rats were hydrated with the corresponding crystalloid and were monitored until arterial pressure dropped below 90 mm Hg (T1, end of supervision, resuscitation baseline). At that time, they received the allocated crystalloid for 200 min for a targeted blood pressure of 90 mmHg. After 200 min, the animals were killed and their urine and plasma were sampled (T2, end of resuscitation)