Fig. 2.

Mitochondrial respiratory activity. jO₂ oxygen flux. a Maximum respiratory activity in the coupled (max OxPhos), leak (LEAK), and uncoupled state (ETS). ^* p ≤ 0.05, ^** p ≤ 0.01, ^*** p ≤ 0.001, ^**** p = ≤ 0.0001. b Maximum respiratory activity in the coupled state depending on complex I activity (Complex I) and maximum respiratory activity in the uncoupled state with inhibition of complex I (Complex II). ^* p ≤ 0.05, ^** p ≤ 0.01, ^*** p ≤ 0.001. All data is presented as median (interquartile range). Kruskal-Wallis analysis of variance on ranks with post hoc Dunn’s test for multiple comparisons