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. 2017 Jun 15;10:190. doi: 10.3389/fnmol.2017.00190

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Copyright © 2017 Tian, Qi, Wang, Wu, Sun, Li, Sha, Du, Chen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of the TRPV4 activation on the dendritic arborization of newborn cells in the hippocampal DG. (A) Representative pictures of the DCX immunostaining in the hippocampal DG in the control and GSK1016790A-injected mice (GSK1016790A: 1 μM/mouse). The molecular layer of the DG was divided into the inner (Mi), middle (Mm), and outer (Mo) subregions. Scale bar = 25 μm. (B) The bar graph shows that the number of DCX⁺ cells was reduced by GSK1016790A treatment. (C) The bar graph shows DCX⁺ fibers in the Mm subregion of the DG decreased in the presence of different doses of GSK1016790A. (D) The dose-dependence curve for the GSK1016790A-induced decrease in DCX⁺ fibers in the Mm subregion. (E) The bar graph shows that the number DCX⁺ fibers in the Mo subregion was decreased by GSK1016790A (1 μM/mouse). ^∗∗p < 0.01 vs. control mice.