FIGURE 5.

Involvement of the AMPK and Akt signaling in the TRPV4 activation-induced impairment of dendritic arborization. DCX immunostaining (A) and the bar graph show that GSK1016790A-induced decreases in DCX⁺ cells (B) and DCX⁺ fibers in the Mm (C) and Mo (D) subregions were attenuated by CC (AMPK antagonist) and 740 Y-P (PI3K agonist), but were unaffected by AICAR (AMPK agonist). ^∗p < 0.05, ^∗∗p < 0.01 vs. control mice, ##p < 0.01 vs. GSK1016790A, &&p < 0.01 vs. 740 Y-P, $$p < 0.01 vs. AICAR.