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Possible mechanisms underlying TRPV4 activation-induced impairment of dendritic arborization of newborn neurons. Activation of TRPV4 impairs the dendritic arborization of newborn neurons in the adult hippocampl DG and this effect is dependent on increasing AMPK activity and inhibiting Akt. The inhibited Akt leads to down-regulate mTOR-p70S6k signaling and increase of GSK3β activity; the increased GSK3β activity results in inhibition of MAP2 and CRMP-2 function ultimately.
