Figure 2.

Celastrol in the treatment of rheumatoid arthritis (RA). Schemes illustrate the main anti-inflammatory properties and molecular targets of celastrol in the physiopathology of RA, as a prototype of an inflammatory disease. Celastrol has several cellular targets, interfering with the production of cytokines, chemokines, and inflammatory mediators; inhibiting cell invasion and proliferation; and suppressing bone resorption and thus constitutes a potential candidate for the treatment of inflammatory diseases.