Table 1.
H-score Evaluation of CYP11B1 and CYP11B2 in NA, IHA and APA.
| Case No. | Age | Sex | Clinical diagnosis | Tumor
|
Adrenal cortex
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Size (mm) | CYP11B1 | CYP11B2 | HSD3B | ZG*
|
ZF
|
ZR
|
||||||||
| CYP11B1 | CYP11B2 | HSD3B | CYP11B1 | CYP11B2 | CYP11B1 | CYP11B2 | ||||||||
| NA 01 | 74 | m | PC | 0.0 | 50.6 | 121.4 | 178.9 | 0.0 | 153.9 | 0.0 | ||||
| NA 02 | 76 | m | RCC | 0.0 | 38.3 | 115.9 | 185.6 | 0.0 | 154.7 | 0.0 | ||||
| NA 03 | 60 | m | RCC | 0.0 | 5.0 | 65.2 | 181.8 | 0.0 | 167.9 | 0.0 | ||||
| NA 04 | 82 | m | RCC | 0.0 | 64.4 | 70.5 | 185.8 | 0.0 | 135.7 | 0.0 | ||||
| NA 05 | 52 | f | RCC | 0.0 | 47.1 | 87.2 | 181.0 | 0.0 | 199.9 | 0.0 | ||||
| NA 06 | 61 | m | PC | 0.0 | 113.9 | 89.3 | 169.4 | 0.0 | 161.0 | 0.0 | ||||
| NA 07 | 71 | f | RCC | 0.0 | 65.5 | 117.3 | 187.1 | 0.0 | 207.7 | 0.0 | ||||
| NA 08 | 71 | m | RCC | 0.0 | 83.2 | 129.9 | 204.3 | 0.0 | 160.6 | 0.0 | ||||
| NA 09 | 75 | m | PC | 0.0 | 37.2 | 116.8 | 189.6 | 0.0 | 192.5 | 0.0 | ||||
| NA 10 | 39 | m | RCC | 0.0 | 80.9 | 64.4 | 186.1 | 0.0 | 167.2 | 0.0 | ||||
| IHA 01 | 30 | m | PA | 0.0 | 51.2 | 128.1 | ||||||||
| IHA 02 | 40 | m | PA | 0.0 | 34.2 | 112.0 | ||||||||
| IHA 03 | 43 | f | PA | 0.0 | 62.7 | 145.1 | ||||||||
| IHA 04 | 32 | f | PA | 0.0 | 97.0 | 141.9 | ||||||||
| IHA 05 | 36 | f | PA | 0.0 | 12.3 | 135.2 | ||||||||
| IHA 06 | 25 | m | PA | 0.0 | 72.5 | 144.0 | ||||||||
| IHA 07 | 44 | m | PA | 0.0 | 84.5 | 155.5 | ||||||||
| IHA 08 | 43 | f | PA | 0.0 | 104.9 | 131.0 | ||||||||
| IHA 09 | 44 | f | PA | 0.0 | 96.0 | 134.0 | ||||||||
| APA 01 | 46 | m | PA | 19.0 | 104.0 | 18.4 | 180.4 | 0.0 | 1.0 | 14.1 | ||||
| APA 02 | 51 | f | PA | 15.0 | 140.0 | 18.9 | 193.6 | 0.0 | 1.1 | 42.6 | ||||
| APA 03 | 62 | m | PA | 12.0 | 47.9 | 32.8 | 190.2 | 0.0 | 0.0 | 121.2 | ||||
| APA 04 | 43 | f | PA | 18.0 | 182.7 | 32.2 | 190.1 | 0.0 | 15.5 | 73.2 | ||||
| APA 05 | 53 | f | PA | 17.0 | 148.2 | 13.5 | 194.3 | 0.0 | 4.9 | 47.6 | ||||
| APA 06 | 51 | f | PA | 20.0 | 0.0 | 43.0 | 200.4 | 0.0 | 45.5 | 115.3 | ||||
| APA 07 | 54 | f | PA | 13.0 | 61.2 | 34.3 | 191.9 | 0.0 | 34.1 | 60.7 | ||||
| APA 08 | 28 | f | PA | 18.0 | 141.4 | 32.0 | 180.1 | 0.0 | 20.5 | 47.3 | ||||
| APA 09 | 52 | f | PA | 37.0 | 188.8 | 32.2 | 164.7 | 0.0 | 60.8 | 76.6 | ||||
| APA 10 | 35 | m | PA | 16.0 | 81.2 | 52.1 | 195.7 | 0.0 | 7.6 | 92.1 | ||||
| APA 11 | 38 | m | PA | 16.0 | 167.0 | 82.4 | 196.3 | 0.0 | 0.0 | 63.3 | ||||
| APA 12 | 37 | m | PA | 12.0 | 1.8 | 26.1 | 192.1 | 0.0 | 8.1 | 73.4 | ||||
| APA 13 | 46 | m | PA | 27.0 | 198.4 | 21.7 | 154.3 | 0.0 | 0.0 | 58.2 | ||||
| APA 14 | 51 | m | PA | 19.0 | 100.3 | 36.7 | 193.5 | 0.0 | 0.0 | 61.2 | ||||
| APA 15 | 50 | m | PA | 16.0 | 78.8 | 106.0 | 193.7 | 0.0 | 5.0 | 27.8 | ||||
| APA 16 | 53 | m | PA | 6.0 | 134.2 | 135.5 | 195.5 | 0.0 | 37.5 | 83.8 | ||||
| APA 17 | 38 | f | PA | 27.0 | 56.2 | 32.1 | 196.2 | 0.0 | 16.0 | 57.5 | ||||
| APA 18 | 36 | f | PA | 17.0 | 122.6 | 71.5 | 197.2 | 0.0 | 76.9 | 62.2 | ||||
| APA 19 | 51 | m | PA | 18.0 | 187.1 | 65.1 | 193.2 | 0.0 | 0.0 | 41.5 | ||||
| APA 20 | 57 | f | PA | 15.0 | 181.1 | 63.3 | 195.9 | 0.0 | 30.7 | 58.6 | ||||
| APA 21 | 44 | m | PA | 28.0 | 174.0 | 56.9 | 184.8 | 0.0 | 0.0 | 40.8 | ||||
| APA 22 | 53 | m | PA | 18.0 | 36.8 | 26.8 | 191.7 | 0.0 | 61.3 | 131.3 | ||||
| APA 23 | 48 | f | PA | 17.0 | 45.4 | 24.9 | 185.8 | 0.0 | 58.6 | 82.0 | ||||
| APA 24 | 51 | m | PA | 17.0 | 53.1 | 23.1 | 195.2 | 0.0 | 0.8 | 100.6 | ||||
| APA 25 | 51 | m | PA | 31.0 | 86.2 | 42.2 | 187.2 | 0.0 | 0.0 | 68.5 | ||||
| APA 26 | 62 | m | PA | 8.0 | 20.6 | 24.1 | 198.3 | 0.0 | 0.0 | 54.7 | ||||
| APA 27 | 59 | m | PA | 10.0 | 66.7 | 52.5 | 192.9 | 0.0 | 54.8 | 49.4 | ||||
| APA 28 | 46 | f | PA | 14.0 | 23.1 | 53.7 | 196.3 | 0.0 | 59.4 | 91.3 | ||||
| APA 29 | 56 | f | PA | 5.0 | 159.4 | 93.7 | 191.3 | 0.0 | 31.2 | 36.4 | ||||
| APA 30 | 59 | m | PA | 17.0 | 171.6 | 33.9 | 185.0 | 0.0 | 74.6 | 74.1 | ||||
| APA 31 | 67 | f | PA | 17.0 | 0.0 | 104.7 | 194.2 | 0.0 | 31.0 | 40.1 | ||||
NA, normal adrenal gland; IHA, idiopathic hyperaldosteronism; APA, aldosterone-producing adenoma; ZG, zona gromerulosa; ZF, zona fasciculata; ZR, zona reticularis; m, male; f, female; PA, primary aldosteronism; PC, pancreas carcinoma; RCC, renal cell carcinoma.
*
ZG of APA was the adjacent adrenal tissue of APA.