Table 4.

Summary of all the fitted parameters in the SHAM model

Parameter	Unit	Definition
$g_{\mathrm{NCX}}=0.0234\times {10}^{-3}$	μm 3 ms–1	Pump rate of NCX
$g_{\mathrm{PMCa}}=0.005\times {10}^{-3}$	μm 3 ms–1	Maximum pump rate of sarcolemmal pump
$K_{\mathrm{PMCa}}=0.35\times {10}^{-3}$	mm	Half saturation of sarcolemmal pump
$g_{\mathrm{SERCA}1}=0.235\times {10}^{-3}$	μm 3 ms–1	Maximum pump rate of SERCA at 1 Hz
$K_{\mathrm{SERCA}1}=0.497\times {10}^{-3}$	mm	Half saturation of SERCA at 1 Hz
$g_{\mathrm{SERCA}6}=0.51\times {10}^{-3}$	μm 3 ms–1	Maximum pump rate of SERCA at 6 Hz
$K_{\mathrm{SERCA}6}=0.69\times {10}^{-3}$	mm	Half saturation of SERCA at 6 Hz
$J_{\mathrm{L}}=8\times {10}^{-4}$	μm 3 ms–1	Permeability of single LCC
$K_{\mathrm{L}}=0.00038$	mm	Concentration at inactivation LCC
$V_{\mathrm{L}}=-9$	mV	Potential when half LCC open
${\delta }_{\mathrm{VL}}=7$	mV	Width of opening potential
${\phi }_{\mathrm{L}}=11.5$	Unitless	Proportion of time closed in open mode LCC
${\tau }_{\mathrm{L}}=1550$	ms	Inactivation time
$g_{\mathrm{D}}=0.1$	μm 3 ms–1	Permeability of the leak current from the dyadic space
$g_{\mathrm{SRL}}=1\times {10}^{-6}$	ms–1	Rate of leak from the SR to the cytosol
$g_{\mathrm{CaB}}=2\times {10}^{-8}$	mm mV–1 ms–1	Background Ca2+ current rate
$g_{\mathrm{t}}=2\times {10}^{-5}$	mS	Permeability of the transient outward potassium current
$g_{\mathrm{ss}}=1.3\times {10}^{-5}$	mS	Permeability of the steady state potassium current
$g_{\mathrm{K}1}=4\times {10}^{-5}$	mS	Permeability of the inward rectifying current
$g_{\mathrm{Na}}=0.0007$	mS	Permeability of the inward sodium current