Table 2.
Biochemical parameters at moments 1 (M1) and 2 (M2) in controls (CTL) and phenylketonuria (PKU) patients.
| M1 |
CTL M1 vs PKU M1 |
M2 |
CTL M1 vs CTL M2 |
PKU M1 vs PKU M2 |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CTL | PKU | p value | CTL | PKU | p value | p value | |||||
| Phe (μmol/L) | 81 ± 24 | (17) | 773 ± 190 | (8) | < 0.001 | 73 ± 15 | (17) | 723 ± 139 | (8) | NS | NS |
| Tyr (μmol/L) | 57 ± 15 | (17) | 62 ± 9 | (8) | NS | 79 ± 20 | (17) | 90 ± 24 | (8) | < 0.001 | NS |
| Phe/Tyr ratio | 1.4 ± 0.2 | (17) | 12.4 ± 2.4 | (8) | < 0.001 | 1.0 ± 0.2 | (17) | 8.3 ± 1.8 | (8) | < 0.001 | NS |
| Tryptophan (μmol/L) | 35 ± 9 | (17) | 29 ± 6 | (8) | NS | 35 ± 8 | (17) | 36 ± 12 | (8) | NS | NS |
| BCAA (μmol/L) | 456 ± 86 | (17) | 332 ± 50 | (8) | 0.001 | 403 ± 63 | (17) | 478 ± 132 | (8) | NS | NS |
| Glucose (mg/dL) | 89 ± 8 | (17) | 83 ± 7 | (8) | NS | 77 ± 9 | (17) | 78 ± 11 | (8) | 0.001 | NS |
| Lactate (mg/dL) | 1.3 ± 0.5 | (17) | 1.3 ± 0.3 | (7) | NS | 3.7 ± 1.6 | (17) | 3.6 ± 1.8 | (7) | < 0.001 | NS |
| Triacylglycerol (mg/dL) | 89 ± 33 | (17) | 76 ± 27 | (8) | NS | 100 ± 39 | (17) | 77 ± 27 | (8) | NS | NS |
| Total cholesterol (mg/dL) | 168 ± 31 | (17) | 121 ± 26 | (8) | 0.001 | 181 ± 34 | (17) | 129 ± 26 | (8) | < 0.001 | < 0.001 |
| HDL (mg/dL) | 54 ± 12 | (17) | 42 ± 6 | (8) | NS | 57 ± 11 | (17) | 45 ± 7 | (8) | < 0.001 | NS |
| LDL (mg/dL) | 97 ± 28 | (17) | 63 ± 19 | (8) | NS | 103 ± 28 | (17) | 68 ± 19 | (8) | 0.001 | 0.001 |
| Dopamine (pg/mL) | 56 ± 15 | (17) | 58 ± 17 | (8) | NS | 57 ± 13 | (17) | 57 ± 11 | (8) | NS | NS |
| Noradrenaline (pg/mL) | 228 ± 77 | (17) | 220 ± 52 | (8) | NS | 229 ± 85 | (17) | 217 ± 53 | (8) | NS | NS |
| Adrenaline (pg/mL) | 49 ± 15 | (17) | 45 ± 12 | (8) | NS | 52 ± 15 | (17) | 43 ± 11 | (8) | NS | NS |
| Adiponectin (ng/mL) | 28 ± 6 | (14) | 37 ± 8 | (8) | NS | 30 ± 9 | (14) | 39 ± 4 | (7) | NS | NS |
Phe, phenylalanine; Tyr, tyrosine; BCAA, branched chain amino acids (isoleucine, leucine, and valine); RER, respiratory exchange ratio; NS, non-significant; N/A, not applicable. Results are expressed as mean ± SD (n), two-sided paired t-test. After applying Bonferroni correction, only results with p < 0.002 were considered significant (see methodology).