Table 1a.

Comparison (Kruskal–Wallis) of dietary regimes regarding median Phe-concentrations (in μmol/l and in % above therapeutic limit), age, Phe-intake, adherence to amino acid mixture and burden of dietary regime for children.

Dietary regime	1	2	3	4	5	p	ᵡ2	df
n	22	25	30	25	6
Age [years]: median (range)	2.5 (1–9)	4.0 (1–9)	5.0 (1–9)	4.0 (1–9)	4.0 (2–9)	0.399	4.052	4
Age [years]: mean (SD)	3.7 (2.9)	4.4 (2.8)	5.1 (2.9)	4.5 (2.3)	4.8(3.1)
Therapeutic range [μmol/l]	42–240	42–240	42–240	42–240	42–240
Median Phe-concentration [μmol/l]	161	229	236	249	288	0.175	6.340	4
Median Phe-concentration [μmol/l]: range	77–829	92–544	75–744	78–531	156–529
Median Phe-concentration [μmol/l]: interquartile range(IQR)	96–285	161–327	176–299	178–292	210–503
Median Phe-concentrations > therapeutic range [%]	17	50	42	50	75	0.035a	10.033	4
Median Phe-concentrations > therapeutic range [%]: range	0–100	0–100	0–100	0–100	0–100
Median Phe-concentrations > therapeutic range [%]: IQR	0–38	17–75	17–83	17–75	25–100
Phe intake [mg]: median (range)	295 (160–590)	290 (180–670)	300 (220–475)	300 (200–700)	570 (250–800)	0.019b	11.341	4
Adherence to amino acid mixture: median (range)	5 (3–5)	5 (4–5)	5 (3–5)	5 (3–5)	5 (2–5)	0.119	6.800	4
Burden of dietary regime: median (range)	3 (1–5)	3 (2–5)	3 (3–5)	3 (1–5)	3 (2–4)	0.070	8.238	4

^aDietary regime 1 vs 2: p = 0.022; 1 vs 3: p = 0.007; 1 vs 4: p = 0.028; 1 vs 5: p = 0.033 (post hoc analyses: Mann–Whitney U)

^bDietary regime 1 vs 5: p = 0.008; 2 vs 5: p = 0.007; 3 vs 5: p = 0.008; 4 vs 5: p = 0.006 (post hoc analyses: Mann–Whitney U)