Figure 2. Schematic diagram showing the potential mechanisms by which familial cardiomyopathy mutations in sarcomeric proteins may cause proteasome dysfunction.

Boxes show changes that have been observed experimentally and the numbers in these boxes correspond to the following references: 1, Baudenbacher et al. (2008); 2, Schober et al. (2012); 3, Gilda et al. (2016); 4, Miller et al. (2001); 5, JE Gilda & AV Gomes, unpublished data; 6, Bahrudin et al. (2008). PTMs, post‐translational modifications.