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. 2017 Mar 2;595(12):4089–4108. doi: 10.1113/JP273714

Figure 7. Fructose‐rich diet brings the sarcoplasmic reticulum closer to the mitochondria through a CaMKII‐mediated pathway.

Figure 7

A, transmission electron micrographs of left ventricle from WT CD and FRD mice. The insets show an amplified section of the photographs at the regions marked with * or #. The amplified photographs were skeletonized to better delineate the limits of each organelle (sarcoplasmic reticulum and mitochondria, M). FRD SR/mitochondria distance is decreased with respect to the distance between CD organelles. B, transmission electron micrographs at higher magnification where the arrows point to the limits between the mitochondria and the SR in WT and AC3I mice. C, average data of the distance between the SR and the mitochondria (Mito‐SR distance). FRD significantly decreased the Mito‐SR distance in WT mice. This remodelling is greatly prevented in the AC3I mice. * P < 0.05 vs. FRD WT, # P < 0.05 vs CD WT, n = 3 mice per group.