Table 1.
Average function data for LANG and LWHs during NSR and at each pacing rate when perfusing with control solution (Control) and after administering TOLB to the perfusate (1 μm)
| LANG | LWH | ||||
|---|---|---|---|---|---|
| Control | TOLB | Control | TOLB | ||
| NSR | Heart rate (beats min–1) | 122 ± 4 | 105 ± 13 | 139 ± 11 | 150 ± 17 |
| MVO2 (μmol O2 g·min–1) | 1.4 ± 0.3 | 2.1 ± 0.1 | 2.1 ± 0.2 | 2.5 ± 0.7 | |
| CFR (mL min−1) | 26 ± 4.6 | 30 ± 8.0 | 26 ± 3.0 | 37 ± 4.1 | |
| LVDP (mmHg) | – | – | 84 ± 2.9 | 93 ± 6.4 | |
| Pacing CL (ms) | |||||
| 330 | MVO2 (μmol O2 g·min–1) | 1.8 ± 0.3 | 2.0 ± 0.1 | 2.4 ± 0.1 | 2.6 ± 0.1 |
| CFR (mL min−1) | 26 ± 4.7 | 39 ± 5.3 | 27 ± 2.0 | 36 ± 1.3 | |
| LVDP (mmHg) | – | – | 71 ± 2.4 | 86 ± 4.3* | |
| 220 | MVO2 (μmol O2 g·min–1) | 2.0 ± 0.5 | 3.0 ± 0.3 | 2.8 ± 0.2 | 3.2 ± 0.2 |
| CFR (mL min−1) | 29 ± 5.9 | 56 ± 3.1* | 28 ± 1.8 | 44 ± 3.3 | |
| LVDP (mmHg) | – | – | 57 ± 4.3 | 78 ± 6.7* | |
| 170 | MVO2 (μmol O2 g·min–1) | 2.1 ± 0.4 | 3.5 ± 0.3 | 2.8 ± 0.4 | 3.0 ± 0.3 |
| CFR (mL min−1) | 30 ± 6.0 | 64 ± 6.7 | 26 ± 2.3 | 40 ± 5.3 | |
| LVDP (mmHg) | – | – | 31 ± 5.9 | 58 ± 12* | |
*Significantly different from the corresponding control.
Values are the mean ± SE. LANG control: n = 7; LANG + TOLB: n = 4. LWH control: n = 8; LWH + TOLB: n = 5. Significance differences between measurements were determined using unpaired t tests.