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. 2017 Jun 8;5(11):e13305. doi: 10.14814/phy2.13305

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© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Detection of expression changes of MMP14 in ccRCC. Top left (“RNA‐seq”): MMP14 mRNA is about 1.46‐logfold increased in ccRCC. Matched normal samples from the same patients are connected by a line to illustrate the expression change. Top right (“Proteomics”): Increased abundance of MMP14 protein in ccRCC. Two samples, patients 27 and 29, showed decrease in MMP14 expression in ccRCC. In RNA sequencing data, MMP14 mRNA levels were increased in ccRCC also for these two patients. Matched normal and ccRCC samples from the same patient are connected to illustrate the expression change. Bottom (“IHC”): Representative immunohistochemistry (IHC) results showing the increased detection of MMP14 epitope in an ccRCC sample (“TU”) in comparison to the matched healthy (“NO”) sample from the same patient.