Table 1.
PC, positive control; Alp, Allupurinol; FC, chloroform fraction; FA, acetone fraction; FEA, ethyl acetate fraction;FE, ethanol fraction.
| Group | Dose (in mg/kg) | Urine volume (ml/24 hours) | Su (in mg/dL) | Sc (in mg/dL) | Uu (in mg/dL) | Uc in (mg/dL) | Fraction excretion of uric acid | BUN (in mg/dL) |
|---|---|---|---|---|---|---|---|---|
| Control | - | 12.15 ± 1.22 | 2.91 ± 0.08 | 0.77 ± 0.03 | 30.03 ± 2.87 | 118.56 ± 5.48 | 8.25 ± 0.39 | 7.22 ± 0.96 |
| PC | - | 18.33 ± 1.04 | 3.60 ± 0.35### | 1.03 ± 0.02## | 19.13 ± 1.93### | 80.36 ± 5.92### | 7.75 ± 0.48# | 10.22 ± 1.28### |
| Alp | 10 | 14.92 ± 1.52 | 2.75 ± 0.25*** | 0.89 ± 0.06*** | 28.52 ± 2.09*** | 89.33 ± 4.62*** | 10.14 ± 0.88*** | 9.31 ± 1.02*** |
| FC | 120 | 17.66 ± 1.85** | 2.52 ± 0.36* | 0.72 ± 0.05* | 27.24 ± 1.94* | 87.25 ± 5.98** | 9.03 ± 0.72** | 8.45 ± 1.28** |
| FA | 200 | 15.42 ± 2.33** | 3.80 ± 0.15** | 1.12 ± 0.07** | 18.88 ± 1.38** | 78.66 ± 6.04** | 9.29 ± 0.36** | 8.52 ± 1.16** |
| FEA | 400 | 15.98 ± 1.87*** | 1.40 ± 0.28*** | 0.66 ± 0.02*** | 33.19 ± 2.64*** | 121.87 ± 7.84*** | 9.38 ± 0.83*** | 8.68 ± 1.08*** |
| FE | 280 | 16.67 ± 2.02** | 2.48 ± 0.18** | 0.71 ± 0.04*** | 32.62 ± 2.18*** | 120.29 ± 5.28*** | 8.66 ± 0.51*** | 8.02 ± 1.32*** |
Results indicating arithmatic mean ± SEM, 10 rats in each group. The statistical analysis conducted using one-way ANOVA and Tukey-Kramer test.
#
p< 0.05,
##
p<0.01 and
###
p< 0.001, compared to control group.
*
p< 0.05,
**
p<0.01 and
***
p< 0.001 compared to positive control group.