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siRNA nanoparticle strategies to augment proposed TNBC subtype-specific therapies
| TNBC subtype | Current proposed therapy | Proposed siRNA nanoparticle strategy |
|---|---|---|
| Basal-like | Cisplatin | siBRCA + cisplatin |
| Mesenchymal | PI3K/mTOR inhibitor | sip110β + MEK inhibitor siPIK3CA mutant + chemo siGF combination siEMT combination |
| Luminal androgen receptor | Bicalutamide | siAR |
GF – growth factor; EMT – Epithelial-mesenchymal transition; AR – Androgen receptor
