Figure 6. The peaks and rates of rise of the Ca²⁺ transients are attenuated by age and graded by FI score in voltage‐clamped ventricular myocytes.

A, representative recordings of Ca²⁺ transients from myocytes isolated from mice with different FI scores. B, scatterplots plus box and whisker plots show that peak Ca²⁺ transients declined with age. C and D, the Ca²⁺ transient rates of rise declined with age, but decay rates were not affected. E–G, Ca²⁺ transient amplitudes and rates of rise were graded by FI, but decay rates were not. Differences between age groups were assessed using a Mann–Whitney Rank Sum test and correlations were evaluated with linear regression (n = 9 adult and 32 aged myocytes). Filled symbols indicate adult mice and open symbols indicate aged mice.