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. 2017 Mar 21;31(7):2881–2892. doi: 10.1096/fj.201601238R

Figure 1.

Figure 1.

Nrp1myel-KO mice demonstrate increased CLP-induced lethality of sepsis. A) Scheme for generating Nrp1myel-KO mice. B) Genotyping analysis of 4-wk-old mice. C) Nrp1 mRNA expression in BMDMs. D) Immunoblot analysis of Nrp1 in PMs and BMDMs. E) Survival rates of WT and Nrp1myel-KO mice (n = 13–24 per group) after sham surgery or CLP procedure. F, G) Inflammatory cytokines in peritoneal lavage (F) and serum (G) 24 h after sham surgery or CLP (n = 7–8 per group per experiment) were measured by ELISA. Data are expressed as means ± sem. *P < 0.05 vs. WT or as indicated.