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. 2017 Mar 21;31(7):2881–2892. doi: 10.1096/fj.201601238R

Figure 2.

Figure 2.

Nrp1myel-KO mice exhibit increased LPS-induced lethality of sepsis. Male 8-wk-old mice were intraperitoneally injected with LPS (40 mg/kg body weight), and mouse death was monitored. A) Survival rates of WT and Nrp1myel-KO mice (n = 16–17 per group). B, C) Inflammatory cytokines in peritoneal lavage (B) and serum (C) 2 h after administration of LPS (5 mg/kg body weight) or saline control (vehicle; n = 8 per group) were measured by ELISA. Data are expressed as means ± sem. *P < 0.05 vs. WT or as indicated.