Figure 3.

CRMP improved whole-body insulin sensitivity. A, B) Glucose infusion rate (GIR) (A) and plasma glucose concentrations (B) during the hyperinsulinemic clamp. C) Glucose clearance. D) Insulin-stimulated glucose uptake in quadriceps. E) Hepatic glucose production. Food was withheld from mice for 6 h before the glucose tolerance test and hyperinsulinemic clamp study. Data are represented as means ± sem. Statistical significance determined by Student’s t test (n = 7–8 per group). EGP, endogenous glucose production.