Table 1.
Kinetic parameters of copeptin.
| AUC (24 h) pmol × h/L |
C
min
(1) pmol/L |
T
min
(1) h |
C
max
(1) pmol/L |
T
max
(1)
h |
C
average pmol/L |
Fluctuation index % |
Baseline copeptin pmol/L |
|
|---|---|---|---|---|---|---|---|---|
| All subjects | ||||||||
| Mean ± SEM | 87.7 ± 7.5 | 2.3 ± 0.2 | 5.18 pm ± 1.1 | 5.9 ± 1.0 | 4.42 am ± 0.6 h | 3.7 ± 0.3 | 120.5 ± 13.6 | 5.7 ± 0.7 |
| Median (range) | 87.8 (52.2–141.1) |
2.2 (1.5–5.2) |
6.30 pm (5.30–12.00 pm) |
4.5 (2.4–19.4) |
5.00 am (0.00–7:30 am) |
3.7 (2.2–5.9) |
113 (72.6–328.5) |
4.8 (2.6–12.6) |
|
| ||||||||
| Subpopulation A: baseline values ≥ median | ||||||||
| Mean ± SEM | 107.7 ± 8.4 | 2.8 ± 0.4 | 7.00 pm ± 0.7 | 8.7 ± 1.7 | 5.54 am ± 0.9 | 4.6 ± 0.4 | 163.4 ± 33.4 | 7.7 ± 0.8 |
| Median (range) | 93.0 (85.2–141.1) |
2.5 (1.6–52) |
7:00 pm (4:00–10.5 pm) |
7.4 (3.3–19.4) |
6.48 am (0.00–7.30 am) |
3.9 (3.5–5.9) |
144.9 (113.8–328.5) |
7.3 (4.81–12.6) |
|
| ||||||||
| Subpopulation B: baseline values < median | ||||||||
| Mean ± SEM | 67.7 ± 6.4 | 1.9 ± 0.1 | 3.48 pm ± 1.8 | 3.7 ± 0.4 | 3.30 am ± 0.9 | 2.8 ± 0.3 | 92.9 ± 6.1 | 3.4 ± 0.2 |
| Median (range) | 59.9 (52.2–100.0) |
1.8 (1.5–3.0) |
4.00 pm (8.30 am–12.00pm) |
3.2 (2.4–6.5) |
3.00 am (0.00–7:30 am) |
2.5 (2.2–4.2) |
88.9 (72.6–113.4) |
3.3 (2.6–4.4) |
|
| ||||||||
| p-value(2) | 0.003 | 0.014 | NS | 0.043 | NS | 0.003 | 0.033 | 0.033 |
SEM = standard error of the mean; (1)measured for the period from 7.5 am to 7.5 am (24 hours); (2)comparing the subgroups (e.g., baseline ≥ median versus baseline < median).