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YM155 synergizes with high-androgen therapy to suppress prostate cancer viability. A) Design of high-throughput screen in LNCaP grown in 10% FBS media supplemented with either 1nM R1881, 10uM Enzalutamide (ENZ), or DMSO. B) Average CellTiter-Glo luciferase signal (viability) for all control wells on drug screen 96 hours post cell seeding. C) Inhibitory concentration for 50% viability (IC50) plotted for various doses of R1881 and D) enzalutamide (ENZ).
