Table 1.
Alteration of Oct4, NEAT1 and MALAT1 expression levels in relation to clinicopathological parameters in 124 lung cancer patients
| Characteristics | Oct4 | NEAT1 | MALAT1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Normal | Overexpression | Normal | Overexpression | Normal | Overexpression | ||||||||||
| n | n | (%) | n | (%) | P a | n | (%) | n | (%) | P a | n | (%) | n | (%) | P a | |
| Overall | 124 | 18 | (14.5) | 106 | (85.5) | 12 | (9.7) | 112 | (90.3) | 14 | (11.3) | 110 | (88.7) | |||
| Tumor stage | ||||||||||||||||
| I + II | 72 | 16 | (22.2) | 56 | (77.8) | 0.005 | 11 | (15.3) | 61 | (84.7) | 0.014 | 12 | (16.7) | 60 | (83.3) | 0.028 |
| III + IV | 51 | 2 | (3.9) | 49 | (96.1) | 1 | (2.0) | 50 | (98.0) | 2 | (3.9) | 49 | (96.1) | |||
| T stage | ||||||||||||||||
| I + II | 104 | 18 | (17.3) | 86 | (82.7) | 0.050 | 11 | (10.6) | 93 | (89.4) | 0.473 | 13 | (12.5) | 91 | (87.5) | 0.361 |
| III + IV | 19 | 0 | (0.0) | 19 | (100.0) | 1 | (5.3) | 18 | (94.7) | 1 | (5.3) | 18 | (94.7) | |||
| N stageb | ||||||||||||||||
| 0 | 71 | 15 | (21.1) | 56 | (78.9) | 0.021 | 11 | (15.5) | 60 | (84.5) | 0.014 | 12 | (16.9) | 59 | (83.1) | 0.029 |
| 1 + 2 | 50 | 3 | (6.0) | 47 | (94.0) | 1 | (2.0) | 49 | (98.0) | 2 | (4.0) | 48 | (96.0) | |||
| M stagec | ||||||||||||||||
| 0 | 116 | 18 | (15.5) | 98 | (84.5) | 0.259 | 12 | (10.3) | 104 | (89.7) | 0.370 | 14 | (12.1) | 102 | (87.9) | 0.329 |
| 1 | 7 | 0 | (0.0) | 7 | (100.0) | 0 | (0.0) | 7 | (100.0) | 0 | (0.0) | 7 | (100.0) | |||
| NEAT1 | ||||||||||||||||
| Normal | 12 | 10 | (83.3) | 2 | (16.7) | <0.001 | − | − | − | − | − | − | − | − | − | |
| Overexpression | 112 | 8 | (7.1) | 104 | (92.9) | − | − | − | − | − | − | − | − | |||
| MALAT1 | ||||||||||||||||
| Normal | 14 | 10 | (71.4) | 4 | (28.6) | <0.001 | 11 | (78.6) | 3 | (21.4) | <0.001 | − | − | − | − | |
| Overexpression | 110 | 8 | (7.3) | 102 | (92.7) | 1 | (0.9) | 109 | (99.1) | − | − | − | − | |||
aThe data were analyzed by Pearson χ2 test. Bold values indicate statistical significance (P < 0.05)
bN Stage: lymph node metastasis
cM Stage: distant metastasis