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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Immunol. 2017 May 3;198(11):4413–4424. doi: 10.4049/jimmunol.1601991

Figure 5. Staphylococcal enterotoxin B induced systemic cytokine/chemokine response in WT and DKO HLA-DR3 mice lacking CD4, CD8 coreceptors.

Figure 5

Eight-week-old WT and DKO HLA-DR3 mice of either sex were challenged with either PBS or SEB (50 μg/mouse). Animals were bled 4 hours later and the concentrations of various cytokines and chemokines in the sera was determined using multiplex bead arrays. Each bar represents mean±SE values from 4-6 mice/group. Solid black bar – WT HLA-DR3 challenged with PBS, bar with slanting lines – WT HLA-DR3 challenged with SEB, Solid white bar – DKO HLA-DR3 challenged with PBS, bar with vertical lines - DKO HLA-DR3 challenged with SEB. * p<0.05, ** p<0.005 and NS – Not significant.