Skip to main content
. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Immunol. 2017 May 3;198(11):4413–4424. doi: 10.4049/jimmunol.1601991

Figure 6. Staphylococcal enterotoxin B induced expansion of splenocytes and deletion of thymocytes in WT and DKO HLA-DR3 mice lacking CD4, CD8 coreceptors.

Figure 6

Eight-week-old WT and DKO HLA-DR3 mice of either sex were challenged with either PBS or SEB (50 μg/mouse). Animals were killed 3 days later. Panel A represents the number of CD3+ splenocytes expressing indicated TCR Vβ families as determined by flow cytometry. Panel B represents fold increase in the absolute numbers of CD3+ T cells expressing TCR Vβ6 and 8 in SEB challenged mice compared to naïve mice. Panel C represents thymocytes gated on the indicated markers. Each bar represents mean±SE values from 4 mice/group. * p<0.05 when compared to respective naive mice and # p<0.05 when compared to SEB-challenged WT DR3 mice.