Figure 9. Chronic exposure to SAg causes expansion of DNT cells.

Ten to twelve weeks-old male and female WT and DKO HLA-DQ8 transgenic mice of were implanted with 7-day mini osmotic pumps delivering either PBS or SEB (50 μg). Spleens were collected at the time of sacrifice and distribution of CD3⁺ T cells bearing TCR Vβ6 and TCR Vβ8 was determined by flow cytometry. Each bar represents mean±SEM from 4-6 mice per group. * p<0.05 when compared to respective PBS-treated mice.