Table 1.

Diagnostic Yield of New Screening Test T Compared with Standard Test S for Colorectal Cancer (CRC), 100,000 Subjects.

Disease	Test Positives			Test Negatives
Status	S+	T+	Δ+	S−	T−	Δ −
Absent	4965	14895	9930	94335	84405	−9930
Presenta	525	630	105	175	70	−105
Ratio	9.5	23.6	94.6	539.1	1205.8	94.6
FP AEsb	33.8	101.3	67.5
ΔFP AEs/ΔTP			0.64

^aPrevalence of disease (CRC) is assumed to be 0.7%, or 700 per 100,000 subjects.

^bRisk of an adverse event during colonoscopy is assumed to be 0.68% (Rutter et al, 2012, Table 2). All subjects falsely testing positive are assumed to be referred to colonoscopy and undergo the procedure.