Table 2.
Baseline characteristics of patients with colorectal cancer aged 15-99 years in QResearch derivation and validation cohorts using information derived from the linked primary care data. Values are numbers (percentages)
| Characteristics | Women | Men | |||
|---|---|---|---|---|---|
| Derivation cohort | Validation cohort | Derivation cohort | Validation cohort | ||
| Total No of patients | 19 708 | 6800 | 24 437 | 8414 | |
| Smoking status: | |||||
| Recorded | 18 405 (93.4) | 6320 (92.9) | 23 044 (94.3) | 7936 (94.3) | |
| Non-smoker | 11 416 (57.9) | 3901 (57.4) | 10 115 (41.4) | 3473 (41.3) | |
| Former smoker | 4898 (24.9) | 1691 (24.9) | 9806 (40.1) | 3347 (39.8) | |
| Light smoker | 1195 (6.1) | 433 (6.4) | 1994 (8.2) | 693 (8.2) | |
| Moderate smoker | 584 (3.0) | 191 (2.8) | 620 (2.5) | 214 (2.5) | |
| Heavy smoker | 312 (1.6) | 104 (1.5) | 509 (2.1) | 209 (2.5) | |
| Alcohol consumption: | |||||
| Recorded | 16 398 (83.2) | 5590 (82.2) | 20 776 (85.0) | 7102 (84.4) | |
| Non-drinker | 7460 (37.9) | 2466 (36.3) | 5160 (21.1) | 1779 (21.1) | |
| Trivial, <1 unit/day | 5701 (28.9) | 2015 (29.6) | 6025 (24.7) | 2079 (24.7) | |
| Light, 1-2 units/day | 1873 (9.5) | 645 (9.5) | 3584 (14.7) | 1225 (14.6) | |
| Moderate or heavy, >3 units/day | 1355 (6.9) | 462 (6.8) | 5965 (24.4) | 2010 (23.9) | |
| Medical history: | |||||
| Family history of bowel cancer | 514 (2.6) | 186 (2.7) | 481 (2.0) | 159 (1.9) | |
| Other cancer | 1570 (8.0) | 553 (8.1) | 1912 (7.8) | 632 (7.5) | |
| CVD | 3054 (15.5) | 1067 (15.7) | 5701 (23.3) | 1984 (23.6) | |
| Type 1 diabetes | 29 (0.1) | 15 (0.2) | 68 (0.3) | 25 (0.3) | |
| Type 2 diabetes | 2207 (11.2) | 766 (11.3) | 3617 (14.8) | 1236 (14.7) | |
| Chronic renal disease | 266 (1.3) | 80 (1.2) | 343 (1.4) | 122 (1.4) | |
| Chronic liver disease | 143 (0.7) | 55 (0.8) | 242 (1.0) | 79 (0.9) | |
| Inflammatory bowel disease | 301 (1.5) | 96 (1.4) | 366 (1.5) | 122 (1.4) | |
| COPD | 1035 (5.3) | 391 (5.8) | 1930 (7.9) | 680 (8.1) | |
| VTE | 901 (4.6) | 295 (4.3) | 939 (3.8) | 357 (4.2) | |
| Prescribed statins at diagnosis | 4258 (21.6) | 1412 (20.8) | 7246 (29.7) | 2440 (29.0) | |
| Prescribed aspirin at diagnosis | 3349 (17.0) | 1179 (17.3) | 5986 (24.5) | 2123 (25.2) | |
| Haemoglobin level recorded | 15 339 (77.8) | 5288 (77.8) | 18 490 (75.7) | 6269 (74.5) | |
| Platelet count recorded | 15 280 (77.5) | 5257 (77.3) | 18 403 (75.3) | 6233 (74.1) | |
| Liver function test result recorded | 14 146 (71.8) | 4869 (71.6) | 17 853 (73.1) | 6037 (71.7) | |
| Haemoglobin <110 g/L | 5581 (28.3) | 1906 (28.0) | 4954 (20.3) | 1716 (20.4) | |
| Raised platelet count | 2321 (11.8) | 791 (11.6) | 1607 (6.6) | 561 (6.7) | |
| Abnormally raised liver function test result | 697 (3.5) | 229 (3.4) | 1188 (4.9) | 401 (4.8) | |
| Body mass index (kg/m2): | |||||
| Recorded | 16 368 (83.1) | 5620 (82.6) | 20 611 (84.3) | 7032 (83.6) | |
| <20 | 1029 (5.2) | 342 (5.0) | 509 (2.1) | 214 (2.5) | |
| 20-24.9 | 5859 (29.7) | 2015 (29.6) | 6158 (25.2) | 2149 (25.5) | |
| 25-29.9 | 5674 (28.8) | 1912 (28.1) | 9268 (37.9) | 3092 (36.7) | |
| 30-34.9 | 2665 (13.5) | 924 (13.6) | 3636 (14.9) | 1236 (14.7) | |
| ≥35 | 1141 (5.8) | 427 (6.3) | 1040 (4.3) | 341 (4.1) | |
CVD=cardiovascular disease; COPD=chronic obstructive pulmonary disease; VTE=venous thromboembolism.