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. 2017 Jun 15;8:21. doi: 10.1186/s13293-017-0143-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Up state activity is enhanced in female mice. LFP traces at a higher and c lower temporal resolution obtained from male (top) and female (bottom) mice. b Bar graphs for Up state duration and d occurrence (Box–Cox transformed for normality) of male (black shade) and female (gray shade) mice. Data in bars are pooled from all ages tested. Insets show line graphs of Up state duration and occurrence in pre-puberty, adult, and old ages. Graphs show mean ± SEM. Asterisks indicate significant sex differences (two-way ANOVA, ***p < 0.001 and **p < 0.01)