Table 1.
Similarity between Antimetabolites and their corresponding human metabolites
| Target Enzyme | Substrate | Antimetabolite | Similarity | P-value |
|---|---|---|---|---|
| TYMS | dUMP | Trifluridine | 0.82 | 1.97E-03 |
| Floxuridine | 0.79 | 6.38E-12 | ||
| Gemcitabine | 0.69 | 2.26E-02 | ||
| Capecitabine | 0.66 | 9.54E-03 | ||
| 5,10-Methylene- tetrahydrofolate |
Pemetrexed | 0.75 | 3.85E-04 | |
| Raltitrexed | 0.75 | 8.57E-10 | ||
| Pralatrexate | 0.69 | 1.40E-09 | ||
| POLA1,POLB | dATP | Cladribine | 0.77 | 1.76E-08 |
| Clofarabine | 0.72 | 6.50E-07 | ||
| Fludarabine | 0.71 | 1.94E-06 | ||
| dGTP | Nelarabine | 0.76 | 3.38E-09 | |
| dCTP | Cytarabine | 0.75 | 7.13E-52 | |
| DHFR | 7,8-Dihydrofolate | Pemetrexed | 0.86 | 7.40E-05 |
| (6S)-5,6,7,8-tetra- hydrofolate(2-) |
Pralatrexate | 0.82 | 6.48E-22 | |
| Methotrexate | 0.78 | 1.88E-05 | ||
| RRM1 | ADP | Fludarabine | 0.8 | 2.28E-08 |
| Clofarabine | 0.73 | 5.95E-05 | ||
| Cladribine | 0.71 | 1.59E-02 | ||
| CDP | Gemcitabine | 0.77 | 6.06E-03 | |
| DNMT1 | Cytidine | Azacitidine | 0.97 | 6.01E-17 |
| Decitabine | 0.88 | 8.06E-12 | ||
| IMPDH1/2 | IMP | Ribavirin | 0.69 | 2.66E-05 |
| ENPP1 | Deamino-NAD+ | Ribavirin | 0.69 | 1.02E-06 |
| ATIC | 10-Formyl- tetrahydrofolate |
Pemetrexed | 0.79 | 7.73E-06 |
| GART | Pemetrexed | 0.79 | 7.73E-06 | |
| NME1/2 | dCDP | Gemcitabine | 0.76 | 1.37E-10 |
| XDH | Hypoxanthine | Allopurinol | 0.69 | 7.90E-12 |