Table 3.

Etiology of CN Model Proposed by Koeck et al

	Skin (OA)	Skin (CN)	Synovium (OA)	Synovium (CN)	Bone (OA)	Bone (CN)
Substance P positive Nerve Fibers	~3.5 nerve fiber per mm2	~3 nerve fiber per mm2	~3 nerve fiber per mm2	~2 nerve fiber per mm2	~4.5 nerve fiber per mm2	~4 nerve fiber per mm2
Sympathetic Nerve Fibers	~7 nerve fiber per mm2	~2 nerve fiber per mm2	~3 nerve fiber per mm2	~0.5 nerve fiber per mm2	~1.5 nerve fiber per mm2	~0.25 nerve fiber per mm2

Density of Substance P Nerve Fibers and Sympathetic Nerve Fibers in Skin, Synovium, and Bone of Patient’s with Charcot Neuroarthropathy and Osteoarthritis

Table is adapted from Koeck et al [56]. In their study they demonstrated that the Charcot joint (synovium) demonstrates a lack of sympathetic control compared to the control sample of patients with osteoarthritic joints. Here we report the approximate mean from their study to demonstrate the difference. The p-value between synovium concentration of sympathetic nerve fibers is <0.006 and indicates a significant difference between the two conditions. It was the only difference between the two groups that was significant