Table 2.
Summary of the 40 T4 mutant structure
| Variant | Mutant PDB ID | Effect | Source |
|---|---|---|---|
| G77A | 1 L23 | Neutral | [64] |
| A82P | 1 L24 | Neutral | [64] |
| A93T | 129 L | Neutral | [65] |
| T151S | 130 L | Neutral | [65] |
| T26S | 131 L | Neutral | [65] |
| V149 M | 1CV6 | Neutral | [66] |
| V87 M | 1CU3 | Destabilizing | [66] |
| S38 N | 1 L61 | Neutral | [67] |
| T109 N | 1 L59 | Neutral | [67] |
| T109D | 1 L62 | Neutral | [67] |
| N116D | 1 L57 | Neutral | [67] |
| D92N | 1 L55 | Destabilizing | [67] |
| S38D | 1 L19 | Neutral | [68] |
| N144D | 1 L20 | Neutral | [68] |
| M106I | 1P46 | Neutral | [69] |
| M120Y | 1P6Y | Neutral | [69] |
| V149I | 1G0Q | Neutral | [70] |
| T152 V | 1G0L | Neutral | [70] |
| V149S | 1G06 | Destabilizing | [70] |
| V149C | 1G07 | Destabilizing | [70] |
| V149G | 1G0P | Destabilizing | [70] |
| E108V | 1QUG | Neutral | [71] |
| L99G | 1QUD | Destabilizing | [71] |
| S117F | 1TLA | Neutral | [72] |
| M106 L | 234 L | Neutral | [73] |
| M120 L | 233 L | Neutral | [73] |
| M106 K | 231 L | Destabilizing | [73] |
| M120 K | 232 L | Destabilizing | [73] |
| I3V | 1 L17 | Neutral | [74] |
| I3Y | 1 L18 | Destabilizing | [74] |
| M102 K | 1 L54 | Destabilizing | [75] |
| T157I | 1 L10 | Destabilizing | [76] |
| G156D | 1 L16 | Destabilizing | [77] |
| R96H | 1 L34 | Destabilizing | [78] |
| I3P | 1 L97 | Destabilizing | [79] |
| R96N | 3CDT | Destabilizing | [80] |
| R96D | 3C8Q | Destabilizing | [80] |
| R96W | 3FI5 | Destabilizing | [80] |
| R96Y | 3C80 | Destabilizing | [80] |
| M102 L | 1 L77 | Destabilizing | [81] |
Forty available T4 lysozyme mutant structures were collected and categorized for their effects. Each mutant is classified based on the literature, where a stabilizing mutation is categorized as “neutral” and a destabilizing mutation is categorized as “destabilizing”