TABLE 4.
Population pharmacokinetic parameters after covariate inclusiona
| Parameter | Population value
|
Interindividual variability (% CV) | Error of estimate (% CV) | |
|---|---|---|---|---|
| Mean | Error of estimate (% CV) | |||
| V1/F | 63.0 | 14.5 | 32.6 | 35.9 |
| V2/(F × Fm) (liters) | 17.3 | 16.1 | 37.0 | 35.3 |
| ka (h−1) | 0.666 | 40.3 | 43.2 | 57.9 |
| k10 (h−1) | 0.097 | 12.9 | 32.4 | 38.3 |
| k12 (h−1) | 0.083 | 10.5 | 19.7 | 43.1 |
| k20 (h−1) | 0.376 | 11.0 | 38.2 | 39.3 |
| ALAG (h) | 0.205 | 40.3 | 98.2 | 75.8 |
a
Residual intraindividual coefficients of variability were 7.6% for NFV and 24.1% for M8. Abbreviations: CV, coefficient of variability; ALAG, lag time. The other abbreviations are defined in the text.