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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: Int Immunopharmacol. 2014 Jul 12;22(2):427–443. doi: 10.1016/j.intimp.2014.06.040

Table 2.

Discordance between published reports of ion channels within gliomas and REMBRANDT microarray-survival data.

Ion channel # over-express # under-express Comments
Potassium Channels
KCNMA1 (BKα) 13 75 trends for inverse relationship with survival
KCNMB1 (BKβ1) 45 2 no correlation with survival
KCNMB2 (BKβ2) 2 126, p=2.21×10−4 less expression the poorer the survival
KCNMB3 (BKβ3) 159, p=0.006 28 more expression the poorer the survival
KCNMB4 (BKβ4) 10 171 no correlation with survival

KCNH3 (Kv12.2) 0 287 no difference in survival
KCNH2 (Kv11.1) 48 7 trend for both with poorer survival
KCNJ2 (Kir2.1) 3 137, p=0.028 less express the better the survival
KCNJ5 (KATP) 12 15, p=0.058 trend for less expression with better survival.
KCNK9 (TASK3) 3 133 trend for over-express with better survival.
Sodium Channels
SCN2A 0 301 no difference in survival
SCN1A 9 93, p=0.037 down-regulation the poorer the survival
Chloride channels
CLCN5 (CLC5) 7 0 no correlation with survival
CLCN3 (CLC3) 0 16, p=0.023 less express with poorer survival
CLCN2 (CLC2) 1 5 no correlation with survival
Acid sensing channels
ACCN2 (ASIC1) 42, p=1.14×10−6 49, p=0.045 over-expression and less-expression gave reverse survival
Transient receptor potential channels
TRPV1 5 15 no correlation with survival
TRPV2 9 31, p=1.88×10−4 less expression the better survival
TRPM8 210, p=3.16×10−8 30 more expression the worse survival
TRPC6 10 21 no correlation with survival
TRPC1 0 73 no correlation with survival
TRPM2 3 53 trend for under-express with better survival
Calcium channels
CACNA1G (Cav3.1) 0 199 no correlation with survival

The ion channels that were discussed in Arcabeli, et al [7] and Ding, et al. [13] dealing with gliomas were examined by REMBRANDT analysis of gene expression and survival for all gliomas (522 patients). The number of patients that had either over-expression (>2.0 fold) or under-expression (<2.0 fold) are reported. If those gene expression/survival profiles do show statistical significance then it is reported along with the correlation towards better or worse survival.