Table 2.
Discordance between published reports of ion channels within gliomas and REMBRANDT microarray-survival data.
Ion channel | # over-express | # under-express | Comments |
---|---|---|---|
Potassium Channels | |||
KCNMA1 (BKα) | 13 | 75 | trends for inverse relationship with survival |
KCNMB1 (BKβ1) | 45 | 2 | no correlation with survival |
KCNMB2 (BKβ2) | 2 | 126, p=2.21×10−4 | less expression the poorer the survival |
KCNMB3 (BKβ3) | 159, p=0.006 | 28 | more expression the poorer the survival |
KCNMB4 (BKβ4) | 10 | 171 | no correlation with survival |
| |||
KCNH3 (Kv12.2) | 0 | 287 | no difference in survival |
KCNH2 (Kv11.1) | 48 | 7 | trend for both with poorer survival |
KCNJ2 (Kir2.1) | 3 | 137, p=0.028 | less express the better the survival |
KCNJ5 (KATP) | 12 | 15, p=0.058 | trend for less expression with better survival. |
KCNK9 (TASK3) | 3 | 133 | trend for over-express with better survival. |
Sodium Channels | |||
SCN2A | 0 | 301 | no difference in survival |
SCN1A | 9 | 93, p=0.037 | down-regulation the poorer the survival |
Chloride channels | |||
CLCN5 (CLC5) | 7 | 0 | no correlation with survival |
CLCN3 (CLC3) | 0 | 16, p=0.023 | less express with poorer survival |
CLCN2 (CLC2) | 1 | 5 | no correlation with survival |
Acid sensing channels | |||
ACCN2 (ASIC1) | 42, p=1.14×10−6 | 49, p=0.045 | over-expression and less-expression gave reverse survival |
Transient receptor potential channels | |||
TRPV1 | 5 | 15 | no correlation with survival |
TRPV2 | 9 | 31, p=1.88×10−4 | less expression the better survival |
TRPM8 | 210, p=3.16×10−8 | 30 | more expression the worse survival |
TRPC6 | 10 | 21 | no correlation with survival |
TRPC1 | 0 | 73 | no correlation with survival |
TRPM2 | 3 | 53 | trend for under-express with better survival |
Calcium channels | |||
CACNA1G (Cav3.1) | 0 | 199 | no correlation with survival |
The ion channels that were discussed in Arcabeli, et al [7] and Ding, et al. [13] dealing with gliomas were examined by REMBRANDT analysis of gene expression and survival for all gliomas (522 patients). The number of patients that had either over-expression (>2.0 fold) or under-expression (<2.0 fold) are reported. If those gene expression/survival profiles do show statistical significance then it is reported along with the correlation towards better or worse survival.