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Ado-R blockade prevents the negative dromotropic effect of m-DITC-ADAC on the guinea pig isolated, perfused heart. The heart was paced at a constant atrial cycle length of 300 msec. CPT (5 μM) prevented the prolongation by m-DITC-ADAC (5 μM) of the SH interval. After washout of CPT in the presence of m-DITC-ADAC, the SH interval rapidly lengthened and remained prolonged despite washout of m-DITC-ADAC. Identical results were obtained in two additional hearts.
