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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: JAMA Oncol. 2016 Jul 1;2(7):922–928. doi: 10.1001/jamaoncol.2016.0256

Figure. Immunohistochemical Analysis (IHC) and Genetic Characteristics of Tumors From 95 Patients With KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumors.

Figure

Five concentric circles depict succinate dehydrogenase (SDH) B expression by IHC (circle A), global tumor DNA methylation (circle B), presence of tumor SDHC promoter methylation including zygosity (circle C), mutations in NF1, BRAF, CBL, ARID1A, KIT/PDGFRA fusion, SDHA, SDHB, SDHC, or SDHD (circle D), and sex (circle E). Tumors are shown in 3 groups: group 1 tumors have normal SDHB expression (n = 11), group 2 tumors have SDHB mutations (n = 63), and group 3 tumors have SDHC promoter methylation (n = 21).

aOne patient in this group was SDHB positive by IHC.

bSee eTable 1 in the Supplement for details.