Table.
Patient Demographics and Tumor Characteristics
| Characteristic | Group 1: SDH-Competent GIST (n = 11) | Group 2: SDHX-Mutant GIST (n = 63) | Group 3: SDHC-Epimutant GIST (n = 21) | All Patients (n = 95) |
|---|---|---|---|---|
| Age, median (range), ya | 46 (30–78) | 23 (7–58) | 15 (8–50) | 23 (7–78) |
| Female sex, No. (%)b | 7 (64) | 39 (62) | 20 (95) | 66 (70) |
| Tumor size at resection, median (range), cm | 8.9 (4.7–13.5) | 5.6 (1.5–21) | 4.7 (2–16) | 5.6 (1.5–21) |
| Focality, proportion (%)c,d | ||||
| Unifocal | 9/10 (90) | 33/55 (60) | 5/18 (28) | 47/83 (57) |
| Multifocal | 1/10 (10) | 22/55 (40) | 13/18 (72) | 36/83 (43) |
| Primary location, No. (%)e | ||||
| Gastric | 1 (9) | 63 (100) | 21 (100) | 85 (89) |
| Small bowel | 9 (82) | 0 | 0 | 9 (9) |
| Abdominal | 1 (9) | 0 | 0 | 1 (1) |
| Histologic subtype, proportion (%)d,f | ||||
| Epithelioid | 1/11 (9) | 22/59 (37) | 9/20 (45) | 32/90 (36) |
| Spindle | 9/11 (82) | 9/59 (15) | 2/20 (10) | 20/90 (22) |
| Mixed | 1/11 (9) | 28/59 (47) | 9/20 (45) | 38/90 (42) |
| Metastasis at presentation, proportion (%)d | ||||
| Liver | 0/10 | 12/58 (21) | 7/19 (37) | 19/87 (22) |
| Peritoneum | 1/10 (10) | 6/58 (10) | 1/19 (5) | 8/87 (9) |
| Lymph nodes | 0/4 | 15/23 (65) | 3/8 (38) | 18/35 (51) |
| No liver or peritoneal metastases at presentation, proportion (%)d | 9/10 (90) | 41/58 (71) | 12/19 (63) | 62/87 (71) |
Abbreviations: GIST, gastrointestinal stromal tumor; SDH, succinate dehydrogenase.
There was a significant difference in age between the 3 groups (P < .001). Pairwise comparisons were significantly different: group 1 vs 2, P < .001; group 1 vs 3, P < .001; group 2 vs 3, P = .002.
There was a significant difference in distribution of sex by group (P = .02); in pairwise comparisons, there was no difference between groups 1 and 2 (P = .91), but the distribution of sex differed significantly between group 1 and group 3 (P = .02) and between group 2 and group 3 (P = .004).
There was a significant difference between focality of presentation for SDH-competent and SDH-deficient GIST (P = .02).
The number of cases is less than the number of patients because of incomplete information.
There was a significant difference in the distribution of primary location of tumors. All group 2 and 3 patients had gastric tumors while 1 of 11 group 1 patients had a gastric tumor (P < .001).
There was a significant difference in histologic subtype among the groups. Group 1 vs 2: P < .001, group 1 vs 3: P < .001, group 2 vs 3: P = .76.