Figure 3.
rRp450 Increases Survival in Orthotopic Mouse Models of Medulloblastoma and AT/RT
Medulloblastoma (D283med, D425med) and AT/RT (BT-12, BT-16) tumors were established in the right frontal lobe of athymic nude mice. Seven days after tumor implantation, the mice received 1 × 106 PFUs of rRp450. Mice treated with rRp450 had significantly longer survival times than mice receiving Opti-MEM vehicle only. Kaplan-Meier curves depict differences in survival and statistical differences determined using the log rank test. D283med, p = 0.0059; D425med, p < 0.0001; BT-12, p = 0.0007; BT-16, p < 0.0001.